Definition of virological breakthrough
VBT is defined as any increase in serum HBV DNA by an amount >1 log10 from nadir or redetection of serum HBV DNA at levels 10-fold over the lower limit of detection of the viral load after HBV DNA becomes undetectable.
Aug 30, 2019
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Jun 30, 2014 · Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
Virologic breakthrough (VBT) may occur in chronic hepatitis B (CHB) patients after switching from nucleos(t)ide analogues (NAs) to pegylated interferon ...
Definitions and HBIG regimens. Virologic breakthrough during antiviral therapy was defined as ≥1 log increase in serum HBV DNA from nadir or redetection of HBV ...
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Jun 30, 2014 · Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
Virologic breakthrough was defined as a confirmed rise in HBV DNA levels, and confirmed HBV DNA rises were those in which the next treatment visit also had ...
Virologic response was defined as achieving undetectable serum HBV DNA level (<20 IU/mL) during the treatment period. Virologic breakthrough was defined as an ...
Sep 23, 2016 · Overall, of the 39 episodes of virologic breakthrough where patients had an opportunity to continue TDF-containing treatment on study, HBV DNA ...
Keywords Chronic HBV, lamivudine, HBeAg, virologic response, virologic breakthrough. Ann Gastroenterol 2014; 27(3): 1-7. Introduction. Approximately one third ...
We investigated the course of virologic breakthrough (VB) after emergence of YMDD mutants in CHB patients receiving lamivudine. Methods: Ninety-three ...
precore mutant hepatitis B virus (HBV) chronic liver disease under long-term lamivudine ... more after virologic breakthrough (HBV DNA, 116,440 copies/mL only on ...
Apr 6, 2024 · Here, we report for the first time a patient with chronic hepatitis B and cirrhosis who emerged with virologic breakthrough during combination ...
Keywords Chronic HBV, lamivudine, HBeAg, virologic response, virologic breakthrough. Ann Gastroenterol 2014; 27 (4): 380-386. Introduction. Approximately one ...
Results: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When ...
... HBV DNA at year 3. The cumulative rate of entecavir-resistant mutations was 1.2% at year 3. Three patients experienced virologic breakthrough, one with ...
None of the patients in group I developed virologic breakthrough, whereas 12% and 25.8% in groups II and III respectively developed breakthrough. In group I, 25 ...
Virologic breakthrough in a patient with chronic hepatitis B by ...
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emerged and were associated with an increase in serum HBV DNA at virologic breakthrough. Long-term therapy with TDF against the ETV-resistant virus has the ...
Monotherapy with tenofovir disoproxil fumarate for multiple drug‐resistant ...
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Transient virologic breakthrough occurred in 6 patients, which was due to poor drug adherence. At week 144, 19 patients who had HBV DNA levels >60 IU/mL ...
Jul 1, 2016 · ... hepatitis B envelop antibody (anti-HBe). No hepatitis B surface antigen (HBsAg) loss and virologic breakthrough were detected in NA-naïve ...
Entecavir for Hepatitis B Liver Disease (BEHoLD) Study Group. In hepatitis B e ... †Virologic breakthrough was defined as an increase in HBV DNA of 1 log in.
Impact of Virologic Breakthrough and HBIG Regimen on Hepatitis B Recurrence After Liver Transplantation · View/Open · Citation · Abstract · Publisher · ISSN · Other ...
... virologic breakthrough or detected HCV RNA levels at the end of treatment). Subjects who did not achieve an SVR for reasons other than virologic failure ...
Nov 14, 2023 · HBV, hepatitis ... for 2 consecutive visits; viral blip: met 1 virologic breakthrough criterion at only 1 visit; viremia: persistent HBV DNA ≥69.
HBV DNA clearance had a virologic breakthrough during the study period ... with chronic hepatitis B and advanced liver disease. N Engl J Med. 2004;351 ...
Partial virologic response is defined as a reduction of greater than 1 log10 IU/ml but detectable HBV DNA by RT PCR assay. Virologic breakthrough or secondary ...
[14] describe five patients with a virologic breakthrough during adefovir dipivoxil. (ADV) treatment in the absence of known ADV-resis- tant mutations, and ...
Oct 17, 2023 · The virologic response was defined as serum HBV DNA below the detection limit (100 IU/mL). The virologic breakthrough was defined as increased ...
Jan 28, 2016 · ... virologic breakthrough (defined as patients with baseline HBV DNA <69 IU/mL and an HBV DNA of ≥69 IU/mL for at least one post-baseline ...
Jan 16, 2014 · Virologic breakthrough during the treatment period was defined as a confirmed increase from the nadir in the HCV RNA level of at least 1 log10 ...
Mar 26, 2010 · ... virologic breakthrough (>1 log10 copies/mL increase in HBV DNA level ... Keywords :Hepatitis B virus; Entecavir; Hepatitis B chronic; Treatment ...
manifests as virologic breakthrough, defined as a !1 log10 IU/mL increase in serum HBV DNA levels from nadir in 2 consecutive samples taken 1 month apart in.
Mar 9, 2017 · Virologic breakthrough (VBT) was defined as an increase over 1 log10 ... a The changes in the mean hepatitis B virus (HBV) DNA levels from ...
Dec 15, 2019 · Predictably, virologic breakthrough was soon demonstrated in a number of lamivudine-treated patients. European, American and most of the ...
Resistant mutations may be detected at the same time or prior to virologic breakthrough (increase in serum HBV DNA by 1 log above nadir). With time, serum HBV ...
... HBV DNA ≥69 IU/mL (because of virologic breakthrough, persistent viremia, or treatment discontinuation with viremia) along with viral phenotyping, were ...
Dec 19, 2023 · Cases of hepatitis B virus (HBV) reactivation, occasionally ... virologic breakthrough (Lawitz, 2014a); (Schneider, 2014). There is ...
The visit window was ±2 weeks. Genotypic analysis was performed at baseline and in cases of virologic breakthrough (increase of HBV DNA levels >1 log IU/mL from ...
term monitoring of HBV DNA. The development of resistance can result in virologic breakthrough and liver complications. Entecavir and tenofovir represent ...
May 7, 2018 · In one study, the HBV DNA in some patients who experienced a virologic breakthrough ... hepatitis B and advanced liver disease. N Engl J ...
Of the 77 patients in the second year treatment cohort, entecavir resistance emerged in six patients, and seven experienced virologic breakthrough (five with ...
New Virologic Tools for Management of Chronic Hepatitis B and C
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hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C ... and detect virologic breakthrough and relapse. Resistance variants should ...
The first manifestation of antiviral resistance is virologic breakthrough which is defined as a >1log10 increase in serum HBV DNA from nadir during treatment in ...
Oct 16, 2014 · A virologic breakthrough was defined as an increase in the serum HBV ... Hepatitis B virus replication and liver disease progression: the ...
B virus (HBV), Hepatitis C virus (HCV) or Hepatitis delta virus (HDV) ... Virologic breakthrough: 1 log increase in HBV DNA levels in comparison with ...
tectable HBV DNA on entecavir, 5 (7%) developed entecavir resistance.58 All patients with entecavir virologic breakthrough at year 5 had HBV virus with.
Apr 8, 2019 · Virologic breakthrough (VBT) was defined as an increase in serum HBV ... hepatitis B and advanced liver disease. N Engl J Med 2004;351:1521 ...
A virologic breakthrough (associated with YMDD detection in 98.6% of the analyzed cases) developed in 198/558 responders to therapy (35.5%) after a mean time of ...
Nov 16, 2015 · Virologic breakthrough was defined as detectable HCV RNA during treatment in a patient who had previously had undetectable HCV RNA. Relapse was ...
... virologic breakthrough characterized by a return to baseline replication levels. ... Entecavir and TDF were reported to reduce the incidence of hepatitis, liver ...
... hepatitis B. However, not all patients who face virologic breakthrough during LAM treatment respond to ADV. The aim of this study was to determine the ...
term monitoring of HBV DNA. The development of resistance can result in virologic breakthrough and liver complications. Entecavir and tenofovir represent ...
Jan 18, 2023 · The only confirmed virologic failure was virologic breakthrough at week 8 in a participant with genotype 3 and cirrhosis. Both regimens were ...
The biochemical and serologic responses, virologic breakthrough, and antiviral resistance rates were also evaluated. ... HBV, hepatitis B virus; HCC, ...
virologic breakthrough. Follow-up and definitions. HBV-DNA was measured at the baseline and every 3 months during the treatment with ETV 0.5 mg once a day by ...
Virologic breakthrough was defined as a confirmed rise in HBV DNA levels, and confirmed HBV DNA rises were those in which the next treatment visit also had ...
Hepatitis C virus (HCV) infection causes acute and chronic hepatitis and ... virologic breakthrough (VBT), reappearance of HCV RNA at any time during ...
Jun 4, 2024 · In the ribavirin-free group, 2 of 42 (5%) treatment-naïve patients had virologic relapse, and 1 of 44 (2%) had virologic breakthrough; no ...
surface antigen; HBV, hepatitis B virus; HCV, hep- atitis C virus; IM ... Virologic breakthrough during antiviral therapy was defined as ≥1 log in-.
Jul 27, 2021 · Clinically, antiviral resistance manifests as virologic breakthrough, defined as a ≥1 log10 IU/mL increase in serum HBV DNA levels from ...
There was no case of virologic breakthrough. An absence of HBeAg and a low serum HBV DNA level (<8 log(10) copies/mL) at baseline were significant ...
Jun 30, 2012 · Virologic breakthrough is defined as an increase in serum HBV DNA of more than 1 log10 (IU/mL) compared to lowest value. Partial virologic ...
Jun 28, 2008 · Virologic breakthrough lagged behind the development of resistance. ... liver caused by hepatitis D virus (HDV). Now real-world studies of ...
Nov 12, 2008 · Clinical Course of Virologic Breakthrough after Emergence of YMDD Mutations in HBeAg-Positive Chronic Hepatitis B · Abstract · Sign in.
Jul 1, 2016 · ... (HIV), hepatitis C virus (HCV) or hepatitis. D virus (HDV); 2 ... HBV patients, and in case of virologic breakthrough, defined as a ...
... virologic breakthrough could develop. Keywords: adefovir · chronic infection · entecavir · hepatitis B · interferon · lamivudine · nucleoside analog ...
In a compliant patient, it is important to distinguish between primary nonresponse, partial virologic response, and virologic breakthrough (viral rebound) owing ...
May 28, 2014 · (hepatitis C virus or hepatitis D virus were excludded). ... experienced virologic breakthrough, one with resistance development ...
Jan 20, 2011 · STEP 7: Manage treatment failure or virologic breakthrough. Page 9. Federal Bureau of Prisons. Detecting, Evaluating, and Treating Chronic HBV ...
Oct 16, 2012 · We assessed risk factors for virologic breakthrough and withdrawal hepatitis. Death without HBV reactivation was regarded as a competing risk ...
High HBV-DNA load before treatment was shown to be an important factor causing virologic breakthrough. Early suppression of viral replication plays a key role ...
Phenotypic resistance is defined as virologic breakthrough (ie, an increase in serum HBV DNA by >1 log10 above nadir after achieving virologic response ...
Aug 30, 2008 · Patients who experienced a virologic breakthrough, defined as two consecutive HBV ... Lamivudine for patients with chronic hepatitis B and ...
Sep 6, 2021 · Patients with persistent HBV viremia (persistent HBV DNA > 100 IU/ml after 48 weeks of antiviral treatment in plasma) or virologic breakthrough ...
Apr 8, 2019 · Virologic breakthrough (VBT) was defined as an increase in serum HBV ... hepatitis B and advanced liver disease. N Engl J Med 2004;351:1521 ...
Aug 14, 2007 · ... HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine." (2007) ...
Feb 23, 2023 · "Impact of virologic breakthrough and HBIG regimen on hepatitis B recurrence after liver transplantation." American Journal of ...
Feb 28, 2018 · "Impact of virologic breakthrough and HBIG regimen on hepatitis B recurrence after liver transplantation. ... liver? Hepatitis and liver disease.
... HCV NS3 variants that emerged during virologic breakthrough and relapse from BI201335 phase 2 SILEN-C1 study. Hepatology 2011;54(Suppl 4):991A. Pilot-Matias ...
... virologic breakthrough and HBIG regimen on hepatitis B recurrence after liver transplantation. Am J Transplant. 2010;10(8):1823–33. Marzano A, Gaia S ...
... virologic breakthrough. In SPRINT-2, SVR rate in non-blacks who attained ≥ 1 log10 decline in HCV RNA after week 4 lead-in was 82% in both BOC treatment ...
... virologic breakthrough, as demonstrated in PROVE 2 where breakthrough occurred in only 2% of patients treated with triple therapy as opposed to 26% of those ...
... HCV genotypes . Sofosbuvir ( GS - 7977 ) is a potent , specific HCV ... virologic breakthrough has been reported in any patient to date . The PROTON ...