Lymphomatoid Papulosis (LyP) is a disorder of the immune system that manifests with self-healing small bumps and spots on the skin that come and go.
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What is the life expectancy of lymphomatoid papulosis?
Prognosis is good, with a normal life expectancy, even if the disease is chronic with recurring lesions and an increased risk of developing second lymphoid neoplasms (4-25% of patients).
Is LyP an autoimmune disease?
What is Lymphomatoid Papulosis? Lymphomatoid papulosis (LyP) is a disease of the immune system that presents with self-healing small bumps and spots on the skin that come and go. It can be persistent, with frequent, recurring eruptions, or it can disappear for an extended period before showing up again.
What triggers lymphomatoid papulosis?
What causes lymphomatoid papulosis? The aetiopathogenesis of primary cutaneous CD30+ lymphoproliferative disorders remains elusive. CD30 signalling is known to affect growth and survival of lymphoid cells. Some studies suggest restriction of the normal T cell repertoire in the peripheral blood.
What is the cause of LyP?
The cause of LyP is not known, but there is no evidence that it is hereditary. Stress is often reported to trigger eruptions of lesions. A diagnosis of LyP requires evaluating the symptoms and having a skin biopsy for various types of laboratory tests.
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LyP-1, Peptide 1 recognizes lymphatics and tumor cells in certain tumors, but not lymphatics in normal tissues.
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Aug 27, 2024 · Lymphomatoid papulosis (LyP) is a chronic papulonecrotic or papulonodular skin disease with histologic features suggestive of a malignant ...
The lymphoid-specific tyrosine phosphatase (Lyp) has generated enormous interest because a single-nucleotide polymorphism in the gene (PTPN22) encoding Lyp ...
