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Pseudohypoparathyreoidismus und Nebennierenrindeninsuffizienz

Ein Fall von Multipler Endokrinopathie bei peripherer Hormonresistenz

Pseudohypoparathyroidism and adrenal insufficiency

A case of multiple endocrinopathy due to hormone resistance

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Summary

Since his childhood a now 31-year-old male showed typical symptoms of parathyroid hormone deficiency with hypocalcemia and hyperphosphatemia.

We found a target organ resistance to parathyroid hormone and diagnosed pseudohypoparathyroidism. In addition adrenal insufficiency with hypocortisolism was seen. Both hormone systems act by stimulating adenylate cyclase. A defective receptor-adenylate cyclase complex may cause this — for the first time described — combination of endocrine insufficiency.

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Abbreviations

AHO:

Albright's Hereditary Osteodystrophy

PHP:

Pseudohypoparathyreoidismus

hPTH:

humanes Parathormon

cAMP:

cyclisches Adenosinmonophosphat

GTP:

Guanosintriphosphat

ACTH:

Adrenocorticotropes Hormon

LH-RH:

Luteinisierendes Hormon — Releasing-Hormon

TRH:

Thyreotropin-Releasing-Hormon

CRH:

Corticotropin-Releasing-Hormon

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  1. Abteilung Endokrinologie und Rheumatologie, Heinrich-Heine-Universität, Düsseldorf

    P. Ridderskamp & R. Schlaghecke

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  1. P. Ridderskamp
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  2. R. Schlaghecke
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Ridderskamp, P., Schlaghecke, R. Pseudohypoparathyreoidismus und Nebennierenrindeninsuffizienz. Klin Wochenschr 68, 927–931 (1990). https://doi.org/10.1007/BF01649041

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  • DOI: https://doi.org/10.1007/BF01649041

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