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Teratoma, Postpubertal-Type

  • Reference work entry
  • First Online:
Uropathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 43 Accesses

Synonyms

Immature teratoma; Mature teratoma

Definition

Teratoma postpubertal type is composed of several types of tissue representing one or more of the different germinal layers.

Clinical Features

  • Incidence

    In adults, pure teratomas account for only 3–7% of GCTs (Mostofi et al. 1987). Postpubertal teratoma is a tumor component in nearly half of mixed GCTs (von Hochstetter and Hedinger 1982).

  • Age

    It occurs in young adults.

  • Sex

    Male.

  • Site

    Testis.

  • Treatment

    Orchifunicolectomy.

  • Outcome

    Teratoma rarely occurs with metastases, showing similar sites of spread as other germ cell tumors. A teratomatous component in the testis is also associated with higher probability of teratoma in post chemotherapy retroperitoneal lymphnodes. The presence of teratoma alone in metastases carries a favorable prognosis compared to persistent non-teratomatous GCT post chemotherapy (Tarrant et al. 2013).

Macroscopy

The macroscopic appearance depends on the amounts of different tissues present in the tumor. The...

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References and Further Reading

  • Cheng, L., Zhang, S., Eble, J. N., Beck, S. D., Foster, R. S., Wang, M., & Ulbright, T. M. (2012). Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma. Modern Pathology, 25(10), 1432–1438.

    Article  CAS  Google Scholar 

  • Jones, T. D., Wang, M., Sung, M. T., Zhang, S., Ulbright, T. M., Eble, J. N., Beck, S. D., Foster, R. S., Anagnostou, J. J., Conner, C., & Cheng, L. (2006). Clonal origin of metastatic testicular teratomas. Clinical Cancer Research, 12(18), 5377–5383.

    Article  CAS  Google Scholar 

  • Mostofi, F. K., Sesterhenn, I. A., & Davis, C. J. (1987). Immunopathology of germ cell tumors of the testis. Seminars in Diagnostic Pathology, 4(4), 320–341.

    CAS  PubMed  Google Scholar 

  • Tarrant, W. P., Czerniak, B. A., & Guo, C. C. (2013). Relationship between primary and metastatic testicular germ cell tumors: A clinicopathologic analysis of 100 cases. Human Pathology, 44(10), 2220–2226.

    Article  Google Scholar 

  • von Hochstetter, A. R., & Hedinger, C. E. (1982). The differential diagnosis of testicular germ cell tumors in theory and practice. A critical analysis of two major systems of classification and review of 389 cases. Virchows Archiv. A, Pathological Anatomy and Histology, 396(3), 247–277.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

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Colecchia, M., Bertolotti, A. (2020). Teratoma, Postpubertal-Type. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4956

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  • DOI: https://doi.org/10.1007/978-3-030-41894-6_4956

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

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