WO2007103182A3 - Compostions and methods for administering gdnf ligand family proteins - Google Patents

Compostions and methods for administering gdnf ligand family proteins Download PDF

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Publication number
WO2007103182A3
WO2007103182A3 PCT/US2007/005366 US2007005366W WO2007103182A3 WO 2007103182 A3 WO2007103182 A3 WO 2007103182A3 US 2007005366 W US2007005366 W US 2007005366W WO 2007103182 A3 WO2007103182 A3 WO 2007103182A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand family
methods
compostions
family proteins
administering
Prior art date
Application number
PCT/US2007/005366
Other languages
French (fr)
Other versions
WO2007103182A2 (en
Inventor
Anthony Rossomando
R Blake Pepinsky
Original Assignee
Biogen Idec Inc
Anthony Rossomando
R Blake Pepinsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Anthony Rossomando, R Blake Pepinsky filed Critical Biogen Idec Inc
Priority to US12/281,077 priority Critical patent/US20100056440A1/en
Priority to ES07752090.6T priority patent/ES2450065T3/en
Priority to EP07752090.6A priority patent/EP1993590B1/en
Publication of WO2007103182A2 publication Critical patent/WO2007103182A2/en
Publication of WO2007103182A3 publication Critical patent/WO2007103182A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

Disclosed are methods of increasing serum exposure of an administered glial cell line-derived neurotrophic factor (GDNF) ligand family protein by administering to a subject via systemic delivery (i) a GDNF ligand family protein, and (ii) an amount of heparin or heparan sulphate that increases serum exposure of the administered GDNF ligand family protein in the subject.
PCT/US2007/005366 2006-03-01 2007-02-27 Compostions and methods for administering gdnf ligand family proteins WO2007103182A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/281,077 US20100056440A1 (en) 2006-03-01 2007-02-27 Compositions and methods for administering gdnf ligand family proteins
ES07752090.6T ES2450065T3 (en) 2006-03-01 2007-02-27 Compositions and methods for the administration of GDNF ligand family proteins
EP07752090.6A EP1993590B1 (en) 2006-03-01 2007-02-27 Compostions and methods for administering gdnf ligand family proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77850906P 2006-03-01 2006-03-01
US60/778,509 2006-03-01

Publications (2)

Publication Number Publication Date
WO2007103182A2 WO2007103182A2 (en) 2007-09-13
WO2007103182A3 true WO2007103182A3 (en) 2008-12-18

Family

ID=38475412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005366 WO2007103182A2 (en) 2006-03-01 2007-02-27 Compostions and methods for administering gdnf ligand family proteins

Country Status (4)

Country Link
US (1) US20100056440A1 (en)
EP (1) EP1993590B1 (en)
ES (1) ES2450065T3 (en)
WO (1) WO2007103182A2 (en)

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US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
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ATE433759T1 (en) 2003-04-18 2009-07-15 Biogen Idec Inc POLYMER CONJUGATED GLYCOSILATED NEUBLASTIN
BRPI0514534A (en) 2004-08-19 2008-06-17 Biogen Idec Inc neublastin variants
US8722862B2 (en) 2004-08-19 2014-05-13 Biogen Idec Ma Inc. Refolding transforming growth factor beta family proteins
TWI501774B (en) * 2006-02-27 2015-10-01 Biogen Idec Inc Treatments for neurological disorders
NZ580947A (en) 2007-05-01 2012-05-25 Biogen Idec Inc Compositions and methods for increasing vascularization
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
FI20070808A0 (en) 2007-10-25 2007-10-25 Mart Saarma Split variants of GDNF and uses thereof
EP2968462B1 (en) 2013-03-15 2020-12-23 The Jackson Laboratory Methods for promoting wound healing and hair growth
EP3256147B8 (en) * 2015-01-18 2020-10-21 Gloriana Therapeutics, Inc. Therapeutic protein formulations

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Also Published As

Publication number Publication date
ES2450065T3 (en) 2014-03-21
WO2007103182A2 (en) 2007-09-13
EP1993590B1 (en) 2013-12-25
US20100056440A1 (en) 2010-03-04
EP1993590A2 (en) 2008-11-26
EP1993590A4 (en) 2009-08-26

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