US5992226A - Apparatus and method for measuring intermolecular interactions by atomic force microscopy - Google Patents
Apparatus and method for measuring intermolecular interactions by atomic force microscopy Download PDFInfo
- Publication number
- US5992226A US5992226A US09/074,541 US7454198A US5992226A US 5992226 A US5992226 A US 5992226A US 7454198 A US7454198 A US 7454198A US 5992226 A US5992226 A US 5992226A
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- US
- United States
- Prior art keywords
- sample
- support member
- compound
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- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
- G01B11/255—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures for measuring radius of curvature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
- G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
- G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
- G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders
- G01Q60/42—Functionalisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
- Y10S977/85—Scanning probe control process
- Y10S977/851—Particular movement or positioning of scanning tip
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
- Y10S977/852—Manufacture, treatment, or detection of nanostructure with scanning probe for detection of specific nanostructure sample or nanostructure-related property
- Y10S977/853—Biological sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
- Y10S977/86—Scanning probe structure
- Y10S977/863—Atomic force probe
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Length Measuring Devices With Unspecified Measuring Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Length Measuring Devices By Optical Means (AREA)
Abstract
Description
Claims (50)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/074,541 US5992226A (en) | 1998-05-08 | 1998-05-08 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
JP2000548680A JP2003505665A (en) | 1998-05-08 | 1999-05-05 | Method and apparatus for measuring interaction between molecules by atomic force microscope, sample holding member for atomic force microscope, and cantilever |
MXPA00010904A MXPA00010904A (en) | 1998-05-08 | 1999-05-05 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy. |
EP99922782A EP1076803B1 (en) | 1998-05-08 | 1999-05-05 | Measuring intermolecular interactions by atomic force microscopy |
PCT/US1999/009696 WO1999058922A1 (en) | 1998-05-08 | 1999-05-05 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
CA002331585A CA2331585C (en) | 1998-05-08 | 1999-05-05 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
DE69910001T DE69910001T2 (en) | 1998-05-08 | 1999-05-05 | MEASURING INTERMOLECULAR INTERACTIONS WITH A GRAPHIC FORCE MICROSCOPE |
AU39701/99A AU752634B2 (en) | 1998-05-08 | 1999-05-05 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
KR1020007012483A KR100642836B1 (en) | 1998-05-08 | 1999-05-05 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
AT99922782T ATE246339T1 (en) | 1998-05-08 | 1999-05-05 | MEASURING INTERMOLECULAR INTERACTIONS USING AN ATOMIC FORCE MICROSCOPE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/074,541 US5992226A (en) | 1998-05-08 | 1998-05-08 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
Publications (1)
Publication Number | Publication Date |
---|---|
US5992226A true US5992226A (en) | 1999-11-30 |
Family
ID=22120112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/074,541 Expired - Fee Related US5992226A (en) | 1998-05-08 | 1998-05-08 | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
Country Status (10)
Country | Link |
---|---|
US (1) | US5992226A (en) |
EP (1) | EP1076803B1 (en) |
JP (1) | JP2003505665A (en) |
KR (1) | KR100642836B1 (en) |
AT (1) | ATE246339T1 (en) |
AU (1) | AU752634B2 (en) |
CA (1) | CA2331585C (en) |
DE (1) | DE69910001T2 (en) |
MX (1) | MXPA00010904A (en) |
WO (1) | WO1999058922A1 (en) |
Cited By (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10051143A1 (en) * | 2000-08-11 | 2002-02-28 | Nanotype Gmbh | Detecting and characterizing binding complexes, useful e.g. for diagnosis, comprises forming sample and reference complexes and determining force required for separation |
US20020042081A1 (en) * | 2000-10-10 | 2002-04-11 | Eric Henderson | Evaluating binding affinities by force stratification and force panning |
US20020072127A1 (en) * | 1998-09-05 | 2002-06-13 | Sofield Carl John | Assay of chemical binding |
US20020076927A1 (en) * | 2000-08-15 | 2002-06-20 | Eric Henderson | Nanoscale molecular arrayer |
DE10117866A1 (en) * | 2001-04-10 | 2002-10-17 | Nanotype Gmbh | Detecting and characterizing binding complexes, useful e.g. for diagnosis, comprises forming sample and reference complexes and determining force required for separation |
US20020172943A1 (en) * | 2000-03-07 | 2002-11-21 | Henderson Eric R. | Device and method of use for detection and characterization of pathogens and biological materials |
US20030013111A1 (en) * | 1999-05-21 | 2003-01-16 | Eric Henderson | Method and apparatus for solid state molecular analysis |
WO2003023363A2 (en) * | 2001-09-12 | 2003-03-20 | Protiveris, Inc. | Microcantilever apparatus and methods for detection of enzymes |
US20030073250A1 (en) * | 1999-05-21 | 2003-04-17 | Eric Henderson | Method and apparatus for solid state molecular analysis |
US20030092016A1 (en) * | 2001-11-09 | 2003-05-15 | Thomas Wiggins | Microfluidics apparatus and methods for use thereof |
WO2003043051A1 (en) * | 2001-11-12 | 2003-05-22 | Nanofactory Instruments Ab | Measurement device for electron microscope |
US20030096309A1 (en) * | 2001-08-29 | 2003-05-22 | Alexis Borisy | Screening system for identifying drug-drug interactions and methods of use thereof |
US20030134273A1 (en) * | 2001-07-17 | 2003-07-17 | Eric Henderson | Combined molecular binding detection through force microscopy and mass spectrometry |
US6612161B1 (en) * | 2002-07-23 | 2003-09-02 | Fidelica Microsystems, Inc. | Atomic force microscopy measurements of contact resistance and current-dependent stiction |
US20030186311A1 (en) * | 1999-05-21 | 2003-10-02 | Bioforce Nanosciences, Inc. | Parallel analysis of molecular interactions |
US20040086883A1 (en) * | 2000-08-11 | 2004-05-06 | Hermann Gaub | Method and device for characterising and/or for detecting a bonding complex |
US6812460B1 (en) * | 2003-10-07 | 2004-11-02 | Zyvex Corporation | Nano-manipulation by gyration |
US20040217345A1 (en) * | 2003-05-01 | 2004-11-04 | Clemson University | DNA-based memory device and method of reading and writing same |
US6813958B2 (en) | 2001-06-21 | 2004-11-09 | The United States Of America As Represented By The Secretary Of Commerce | Method for combinatorially measuring adhesion strength |
US20040253642A1 (en) * | 2003-06-06 | 2004-12-16 | Grant Zimmermann | System and method for multidimensional evaluation of combinations of compositions |
US20050034512A1 (en) * | 2003-08-11 | 2005-02-17 | Su Chanmin Quanmin | System for wide frequency dynamic nanomechanical analysis |
US20050084855A1 (en) * | 2001-06-01 | 2005-04-21 | Kerstin Blank | Method for determining an analyte |
US20050239193A1 (en) * | 2002-05-30 | 2005-10-27 | Bioforce Nanosciences, Inc. | Device and method of use for detection and characterization of microorganisms and microparticles |
US20060035234A1 (en) * | 2003-01-02 | 2006-02-16 | Eric Henderson | Method and apparatus for molecular analysis in small sample volumes |
US7042488B2 (en) | 2001-09-27 | 2006-05-09 | Fujinon Corporation | Electronic endoscope for highlighting blood vessel |
US20060177877A1 (en) * | 2000-07-07 | 2006-08-10 | Stockwell Brent R | Methods for identifying combinations of entities as therapeutics |
US20070109636A1 (en) * | 2005-06-10 | 2007-05-17 | Olympus Corporation | Specimen stage array for scanning probe microscope |
WO2007079269A2 (en) * | 2005-12-31 | 2007-07-12 | Carbon Nanoprobes, Inc. | Atomic force microscope tip arrays and methods of manufacturing same |
US20070186629A1 (en) * | 2006-02-10 | 2007-08-16 | Ying-Lan Chang | Functionalizable nanowire-based AFM probe |
US20070227273A1 (en) * | 2005-11-29 | 2007-10-04 | Drexel University | Integrated system for simultaneous inspection and manipulation |
US20080187780A1 (en) * | 2007-02-01 | 2008-08-07 | Seagate Technology Llc | Wear resistant data storage device |
US20110269649A1 (en) * | 2000-08-09 | 2011-11-03 | California Institute Of Technology | Active nems arrays for biochemical analyses |
CN103676127A (en) * | 2013-12-31 | 2014-03-26 | 爱威科技股份有限公司 | Supporting device for microscope, microscope and microscope carrier |
US20140186824A1 (en) * | 2011-07-01 | 2014-07-03 | Ohio University | Dynamic biochemical tissue analysis assays and compositions |
TWI474004B (en) * | 2012-07-13 | 2015-02-21 | Nat Univ Tsing Hua | Multi-head probe with manufacturing and scanning method thereof |
US9816988B1 (en) | 2016-08-10 | 2017-11-14 | Multerra Bio, Inc. | Apparatuses and methods for detecting molecules and binding energy |
EP3431982A1 (en) * | 2017-07-18 | 2019-01-23 | Nanosurf AG | Microcantilever |
US10444179B2 (en) | 2016-08-10 | 2019-10-15 | Multerra Bio, Inc. | Apparatuses and methods for detecting molecules and binding energy |
US11112427B2 (en) | 2019-10-17 | 2021-09-07 | Imec Vzw | Method and tip substrate for scanning probe microscopy |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE33387E (en) * | 1985-11-26 | 1990-10-16 | International Business Machines Corporation | Atomic force microscope and method for imaging surfaces with atomic resolution |
GB2235049A (en) * | 1989-06-20 | 1991-02-20 | Rosser Roy J | Chemical bond microscopy |
US5047663A (en) * | 1989-07-28 | 1991-09-10 | Dallas Semiconductor Corporation | Low-power comparator which tolerates high-slew-rate incoming signals and deriving power from the incoming signals |
US5106729A (en) * | 1989-07-24 | 1992-04-21 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Method for visualizing the base sequence of nucleic acid polymers |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5144833A (en) * | 1990-09-27 | 1992-09-08 | International Business Machines Corporation | Atomic force microscopy |
US5204581A (en) * | 1990-07-12 | 1993-04-20 | Bell Communications Research, Inc. | Device including a tapered microminiature silicon structure |
US5253516A (en) * | 1990-05-23 | 1993-10-19 | Digital Instruments, Inc. | Atomic force microscope for small samples having dual-mode operating capability |
US5260824A (en) * | 1989-04-24 | 1993-11-09 | Olympus Optical Co., Ltd. | Atomic force microscope |
USRE34489E (en) * | 1989-03-13 | 1993-12-28 | The Regents Of The University Of California | Atomic force microscope with optional replaceable fluid cell |
US5363697A (en) * | 1991-04-30 | 1994-11-15 | Matsushita Electric Industrial Co., Ltd. | Scanning probe microscope, molecular processing method using the scanning probe microscope and DNA base arrangement detecting method |
US5372930A (en) * | 1992-09-16 | 1994-12-13 | The United States Of America As Represented By The Secretary Of The Navy | Sensor for ultra-low concentration molecular recognition |
US5463897A (en) * | 1993-08-17 | 1995-11-07 | Digital Instruments, Inc. | Scanning stylus atomic force microscope with cantilever tracking and optical access |
US5519212A (en) * | 1992-08-07 | 1996-05-21 | Digital Instruments, Incorporated | Tapping atomic force microscope with phase or frequency detection |
US5624845A (en) * | 1995-03-16 | 1997-04-29 | International Business Machines Corporation | Assembly and a method suitable for identifying a code |
US5763768A (en) * | 1997-03-17 | 1998-06-09 | Iowa State University Research Foundation, Inc. | Analytical method using modified scanning probes |
US5874668A (en) * | 1995-10-24 | 1999-02-23 | Arch Development Corporation | Atomic force microscope for biological specimens |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0788149A1 (en) * | 1996-02-05 | 1997-08-06 | Hitachi Europe Limited | Method of depositing nanometre scale particles |
DE19631326A1 (en) * | 1996-08-02 | 1998-02-05 | Basf Ag | Drug screening method using atomic force microscopy |
-
1998
- 1998-05-08 US US09/074,541 patent/US5992226A/en not_active Expired - Fee Related
-
1999
- 1999-05-05 JP JP2000548680A patent/JP2003505665A/en active Pending
- 1999-05-05 AT AT99922782T patent/ATE246339T1/en not_active IP Right Cessation
- 1999-05-05 WO PCT/US1999/009696 patent/WO1999058922A1/en active IP Right Grant
- 1999-05-05 KR KR1020007012483A patent/KR100642836B1/en not_active IP Right Cessation
- 1999-05-05 MX MXPA00010904A patent/MXPA00010904A/en not_active IP Right Cessation
- 1999-05-05 DE DE69910001T patent/DE69910001T2/en not_active Expired - Lifetime
- 1999-05-05 EP EP99922782A patent/EP1076803B1/en not_active Expired - Lifetime
- 1999-05-05 AU AU39701/99A patent/AU752634B2/en not_active Ceased
- 1999-05-05 CA CA002331585A patent/CA2331585C/en not_active Expired - Fee Related
Patent Citations (19)
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USRE34489F1 (en) * | 1989-03-13 | 1999-12-14 | Univ California | Atomic force microscope with optimal replacement fluid cell |
USRE34489E (en) * | 1989-03-13 | 1993-12-28 | The Regents Of The University Of California | Atomic force microscope with optional replaceable fluid cell |
US5260824A (en) * | 1989-04-24 | 1993-11-09 | Olympus Optical Co., Ltd. | Atomic force microscope |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5445934A (en) * | 1989-06-07 | 1995-08-29 | Affymax Technologies N.V. | Array of oligonucleotides on a solid substrate |
GB2235049A (en) * | 1989-06-20 | 1991-02-20 | Rosser Roy J | Chemical bond microscopy |
US5106729A (en) * | 1989-07-24 | 1992-04-21 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Method for visualizing the base sequence of nucleic acid polymers |
US5047663A (en) * | 1989-07-28 | 1991-09-10 | Dallas Semiconductor Corporation | Low-power comparator which tolerates high-slew-rate incoming signals and deriving power from the incoming signals |
US5253516A (en) * | 1990-05-23 | 1993-10-19 | Digital Instruments, Inc. | Atomic force microscope for small samples having dual-mode operating capability |
US5204581A (en) * | 1990-07-12 | 1993-04-20 | Bell Communications Research, Inc. | Device including a tapered microminiature silicon structure |
US5144833A (en) * | 1990-09-27 | 1992-09-08 | International Business Machines Corporation | Atomic force microscopy |
US5363697A (en) * | 1991-04-30 | 1994-11-15 | Matsushita Electric Industrial Co., Ltd. | Scanning probe microscope, molecular processing method using the scanning probe microscope and DNA base arrangement detecting method |
US5519212A (en) * | 1992-08-07 | 1996-05-21 | Digital Instruments, Incorporated | Tapping atomic force microscope with phase or frequency detection |
US5372930A (en) * | 1992-09-16 | 1994-12-13 | The United States Of America As Represented By The Secretary Of The Navy | Sensor for ultra-low concentration molecular recognition |
US5463897A (en) * | 1993-08-17 | 1995-11-07 | Digital Instruments, Inc. | Scanning stylus atomic force microscope with cantilever tracking and optical access |
US5624845A (en) * | 1995-03-16 | 1997-04-29 | International Business Machines Corporation | Assembly and a method suitable for identifying a code |
US5874668A (en) * | 1995-10-24 | 1999-02-23 | Arch Development Corporation | Atomic force microscope for biological specimens |
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"Ultrasharp Silicon Gratings" NT-MDT web site at http://www.ntmdt.ru/grating.htm and http://www.ntmdt.ru/manual/silgrat.htm. |
Allen S. et al., "Detection of Antigen-Antibody Binding Events with the Atomic Force Microscope" Biochemistry, vol. 36, No. 24 (1997) pp. 7457-7463. |
Allen S. et al., Detection of Antigen Antibody Binding Events with the Atomic Force Microscope Biochemistry, vol. 36, No. 24 (1997) pp. 7457 7463. * |
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Chilikoti et al., The Relationship Between Ligand Binding Thermodynamics and Protein Ligand Interaction Forces Measured by Atomic Force Microscopy Biophysical Journal vol. 69 (Nov. 1995) pp. 2125 2130. * |
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Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020072127A1 (en) * | 1998-09-05 | 2002-06-13 | Sofield Carl John | Assay of chemical binding |
US20030186311A1 (en) * | 1999-05-21 | 2003-10-02 | Bioforce Nanosciences, Inc. | Parallel analysis of molecular interactions |
US20030073250A1 (en) * | 1999-05-21 | 2003-04-17 | Eric Henderson | Method and apparatus for solid state molecular analysis |
US20030013111A1 (en) * | 1999-05-21 | 2003-01-16 | Eric Henderson | Method and apparatus for solid state molecular analysis |
US6998228B2 (en) | 1999-05-21 | 2006-02-14 | Bioforce Nanosciences, Inc. | Method and apparatus for solid state molecular analysis |
US20020172943A1 (en) * | 2000-03-07 | 2002-11-21 | Henderson Eric R. | Device and method of use for detection and characterization of pathogens and biological materials |
US6897015B2 (en) | 2000-03-07 | 2005-05-24 | Bioforce Nanosciences, Inc. | Device and method of use for detection and characterization of pathogens and biological materials |
US20060177877A1 (en) * | 2000-07-07 | 2006-08-10 | Stockwell Brent R | Methods for identifying combinations of entities as therapeutics |
US20040253627A1 (en) * | 2000-07-07 | 2004-12-16 | Grant Zimmermann | System and method for multidimensional evaluation of combinations of compositions |
US8329452B2 (en) * | 2000-08-09 | 2012-12-11 | California Institute Of Technology | Active NEMS arrays for biochemical analyses |
US20110269649A1 (en) * | 2000-08-09 | 2011-11-03 | California Institute Of Technology | Active nems arrays for biochemical analyses |
DE10051143C2 (en) * | 2000-08-11 | 2002-07-11 | Nanotype Gmbh | Method and device for characterizing and / or detecting a binding complex |
US20040086883A1 (en) * | 2000-08-11 | 2004-05-06 | Hermann Gaub | Method and device for characterising and/or for detecting a bonding complex |
DE10051143A1 (en) * | 2000-08-11 | 2002-02-28 | Nanotype Gmbh | Detecting and characterizing binding complexes, useful e.g. for diagnosis, comprises forming sample and reference complexes and determining force required for separation |
US20020123135A1 (en) * | 2000-08-15 | 2002-09-05 | Eric Henderson | Nanoscale molecular arrayer |
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CA2331585C (en) | 2008-12-09 |
KR20010071224A (en) | 2001-07-28 |
JP2003505665A (en) | 2003-02-12 |
EP1076803B1 (en) | 2003-07-30 |
DE69910001T2 (en) | 2004-04-15 |
EP1076803A4 (en) | 2001-07-25 |
EP1076803A1 (en) | 2001-02-21 |
AU752634B2 (en) | 2002-09-26 |
CA2331585A1 (en) | 1999-11-18 |
ATE246339T1 (en) | 2003-08-15 |
MXPA00010904A (en) | 2002-05-08 |
DE69910001D1 (en) | 2003-09-04 |
KR100642836B1 (en) | 2006-11-03 |
AU3970199A (en) | 1999-11-29 |
WO1999058922A1 (en) | 1999-11-18 |
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