CN102657720A - Traditional Chinese medicine for treating diabetic dyslipidemia - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating diabetic dyslipidemia, and belongs to the field of traditional Chinese medicines for treating diabetes, and the traditional Chinese medicine for treating diabetic dyslipidemia is good in effect and quick in effect taking. The traditional Chinese medicine is prepared from the raw materials such as adenophora stricta, hawthorn, salvia miltiorrhiza, ganoderma lucidum and tienchi ginseng, has the effects of supporting body resistance, reinforcing qi and nourishing blood, promoting blood circulation to remove blood stasis, and lowering lipid, and has the advantages of being good in effect and quick in effect taking.

Description

A kind of Chinese medicine of treating the diabetic dyslipidemia

Technical field

The invention belongs to the field of Chinese medicines of treatment diabetes.

Background technology

In the diabetics,, be referred to as the diabetic dyslipidemia because the biological regulating action generation obstacle of insulin often with the disorder of lipid metabolism, abnormalities of sugar/lipid metabolism occurs.Be often referred in the blood plasma cholesterol with (or) triglyceride increases unusually.These unusual lipidosiss that raise form AP on blood vessel wall, cause vascular wall narrow even inaccessible, cause angina pectoris, myocardial infarction, the cerebral infarction serious consequence of waiting indefinitely, life threatening.According to statistics, have in the diabetics or people's blood fat increase unusually, commonplace.Be used to treat the Chinese medicine of diabetic dyslipidemia at present; Exist some significantly not enough: the one, effect is obvious inadequately; The 2nd, it is slower to take effect; A large amount of patients since the treatment that can not get active drug all the year round dyslipidemia increase, triglyceride, T-CHOL etc. are high in the blood, are faced with the danger that arteriosclerosis increases the weight of, suffers from hypertension, coronary heart disease constantly.Patient and family members are very dissatisfied to this.

To problem set forth above, the present invention provides a kind of Chinese medicine of treating the diabetic dyslipidemia, and it is obvious inadequately that it can solve in this type of treatment by Chinese herbs in the past effect; The slower problem that takes effect, effective, instant effect, it is remarkable to have effect; Drug effect is definite, the advantage of quick result.

Summary of the invention

The present invention realizes through following technical scheme:

1, a kind of Chinese medicine of treating the diabetic dyslipidemia adopts the raw material of Chinese medicine preparation, and prescription is by weight being:

Radix Adenophorae (Radix Glehniae) 4---10 parts of 7 portions of Fructus Crataegis 6---10 parts of Radix Salviae Miltiorrhizaes 6---

9 parts of Ganodermas 6---10 portions of Radix Notoginseng 5---

The Chinese medicine of this treatment diabetic dyslipidemia is processed by following method:

(1) by above-mentioned weight ratio, Ganoderma is extracted ganoderan with decoction and alcohol sedimentation technique, technological process is following: Ganoderma is broken into graininess, crosses 40 mesh sieves →Hot water (95 ℃) lixiviate with 1:20 →Lixiviating solution decompression, concentrated →95% ethanol with 3 times of volumes mixes, left standstill 10-12 hours, centrifugal →Add 75% ethanol, the deposition polysaccharide →Dry the ganoderan extract fine powder;

(2) by above-mentioned weight ratio, Radix Notoginseng is extracted with the alcoholysis water extraction, method is; With Notoginseng Root with 1.6 times of 70% alcohol desorption after; With 20 times of water level volumes 45 ℃ and-P boiling extraction in reducing pressure under the 0.084MPa, extract 4min/ time 2 times; Extracting solution directly adopts macroporous resin to carry out adsorbing separation and gets extract Radix Notoginseng total arasaponins fine powder after concentrating;

(3) by above-mentioned weight ratio, Radix Adenophorae (Radix Glehniae), Fructus Crataegi, Radix Salviae Miltiorrhizae are extracted through conventional water extraction process, process the extract fine powder, mix, stir, process Chinese medicine granules, capsule, tablet with above-mentioned (1), (2) two kinds of extract fine powders.

The present invention is according to the folk tradition prescription, and the theory according to traditional Chinese medical science the body resistance strengthening and constitution consolidating, blood circulation promoting and blood stasis dispelling develops meticulously.We think that the pathogenesis that the diabetic dyslipidemia increases mainly belongs to " void ", " heat " and " stasis of blood " at research.The most hypoimmunities of diabetics are given birth in the deficiency-heat, and the bright body fluid of consumption causes two problems for blood and blood vessel: the one, and lipid (cholesterol, triglyceride) row unnecessary in the blood does not go out, and is detained in the blood, promotes the rising of blood stickiness; The 2nd, low density cholesterol (bad cholesterol) concentration raises in the blood, is deposited on the blood vessel wall, has quickened sclerosis of blood vessels, and can clear up high density cholesterol (good cholesterol) lowering of concentration of fat speckle on the blood vessel wall, thereby formed the unusual of blood fat.In view of the above, the present invention gives prominence to and sets upright, enhancing human body immunity power, sets upright reinforcement with blood circulation promoting and blood stasis dispelling organically to combine, and obtains remarkable result.Among the we, the Ganoderma the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, the tonification the five internal organs, enhancing human body immunity power, " removing " effect of immunity is a key factor of removing unnecessary lipid, high density lipoprotein increasing, reduction low density lipoprotein, LDL in the blood; 5 with Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, and three flavors all are blood circulation promoting and blood stasis dispelling medicines, and " Radix Salviae Miltiorrhizae simply, merit is with four things ", Radix Salviae Miltiorrhizae can passage, nourishing bloods, again can blood circulation promoting and blood stasis dispelling, and simultaneously, Radix Salviae Miltiorrhizae calm the nerves relieving restlessness and removing heat from blood have the merit of YIN nourishing and the production of body fluid promoting; The Radix Notoginseng blood stasis dispelling analgesic therapy of invigorating blood circulation can just not hindered again in blood stasis dispelling, and Zhang Xichun is referred to as " blood stasis dispelling blood and do not hinder fresh blood, fair be treating blood disorders quality goods "; The circulation of qi promoting of Fructus Crataegi dissipating blood stasis, modern pharmacological research, Fructus Crataegi fluid extract can make the laboratory animal blood fat obviously reduce, and the merit that three distinguish the flavor of share the dissipating blood stasis blood stasis dispelling is more outstanding; Assistant is cold in nature with Radix Adenophorae (Radix Glehniae), and replenishing YIN and removing heat is to separate the heat of quenching one's thirst.All medicine compatibilities bring out the best in each other, and play the body resistance strengthening and constitution consolidating altogether, benefiting QI and nourishing blood, the merit of blood circulation promoting and blood stasis dispelling blood fat reducing, have effective, the advantage of instant effect.

The specific embodiment

Through following embodiment the present invention is done and to specify:

1, get following prescription (weight is unit by gram):

Radix Adenophorae (Radix Glehniae) 400 Keshan short, bristly hair or beards 600 gram Radix Salviae Miltiorrhizaes 600 grams

Ganoderma 600 gram Radix Notoginseng 500 grams

Press predetermined weight, Ganoderma is extracted with the method for content of the present invention (1); Method with content of the present invention (2) is extracted Radix Notoginseng; With conventional water extraction process Radix Adenophorae (Radix Glehniae), Fructus Crataegi, Radix Salviae Miltiorrhizae are extracted, process extract fine powder 270 grams altogether, above-mentioned three kinds of extract fine powders are mixed; Stir, process fine particle, the capsule of packing into No. 0; Process 900 of Chinese medicinal capsules, every capsules includes Chinese medicine extract 0.3 gram.

2, get following prescription (weight is unit by gram):

Radix Adenophorae (Radix Glehniae) 700 Keshan short, bristly hair or beards 1000 gram Radix Salviae Miltiorrhizaes 1000 grams

Ganoderma 1000 gram Radix Notoginseng 900 grams

By above-mentioned same method, process 1533 of Chinese medicinal capsules, every capsules includes Chinese medicine extract 0.3 gram.

3, get following prescription (by weight):

7 parts of 7 parts of Radix Salviae Miltiorrhizaes of 5 portions of Fructus Crataegis of Radix Adenophorae (Radix Glehniae)

6 parts of 7 portions of Radix Notoginseng of Ganoderma

By above-mentioned same method, process Chinese medicinal capsule, every capsules includes Chinese medicine extract 0.3 gram.

4, get following prescription (by weight):

9 parts of 9 parts of Radix Salviae Miltiorrhizaes of 6 portions of Fructus Crataegis of Radix Adenophorae (Radix Glehniae)

8 parts of 9 portions of Radix Notoginseng of Ganoderma

By above-mentioned same method, process Chinese medicinal capsule, every capsules includes Chinese medicine extract 0.3 gram.

Clinical data:

The present invention is an example with traditional Chinese medical science diabetic dyslipidemia, through 17 routine clinical observations.Select tcm diagnosis diabetic dyslipidemia to increase and be standard: diabetics serum inspection on an empty stomach has hyperlipemia---total triglyceride>and 150mg/dl (normal value 70---150), T-CHOL>200 mg/dl (normal value 129---179), HDL-C≤35 mg/dl (normal value 23---67), low-density lipoprotein cholesterol>=160 mg/dl; As above index can be made a definite diagnosis.In making a definite diagnosis the object of observation, male's 8 examples, women's 9 examples do not have other serious disease, and the age is 41 years old-75 years old, 59.7 years old mean age.

Efficacy determination:

1, produce effects: reach following each person: T-CHOL fall >=20%, triglyceride fall >=40%, HDL-C ascending amount >=0.26mmoI/L.

2, effective: the T-CHOL fall is not less than 10%, and the triglyceride fall is not less than 20%, HDL-C ascending amount 0.104.

3, invalid: as not reach effective standard.

During clinical experiment, withdraw other medicines and health nutrient.Taking the Chinese medicinal capsule that embodiment of the present invention 1 is made, observed 3 months, is a course of treatment.Instructions of taking: every day 2 times, each 4 capsules, every capsules include Chinese medicine extract 0.3 gram, warm water delivery service after meal, index promptly has alleviation after 1 month, take 3 months after, index is obviously improved.17 philtrums of clinical experiment, produce effects 7 people, effective 8 people, invalid 2 people, total effective rate 88.2%.

Claims (1)

1. Chinese medicine of treating the diabetic dyslipidemia is characterized in that: said Chinese medicine is to adopt the raw material of Chinese medicine preparation, and the weight proportion of raw material of Chinese medicine is:

Radix Adenophorae (Radix Glehniae) 4---10 parts of 7 portions of Fructus Crataegis 6---10 parts of Radix Salviae Miltiorrhizaes 6---

9 parts of Ganodermas 6---10 portions of Radix Notoginseng 5---

The Chinese medicine of this treatment diabetic dyslipidemia is processed by following method:

(1) by above-mentioned weight ratio, Ganoderma is extracted ganoderan with decoction and alcohol sedimentation technique, technological process is following: Ganoderma is broken into graininess, crosses 40 mesh sieves →Hot water (95 ℃) lixiviate with 1:20 →Lixiviating solution decompression, concentrated →95% ethanol with 3 times of volumes mixes, left standstill 10-12 hours, centrifugal →Add 75% ethanol, the deposition polysaccharide →Dry the ganoderan extract fine powder;

(2) by above-mentioned weight ratio, Radix Notoginseng is extracted with the alcoholysis water extraction, method is; With Notoginseng Root with 1.6 times of 70% alcohol desorption after; With 20 times of water level volumes 45 ℃ and-P boiling extraction in reducing pressure under the 0.084MPa, extract 4min/ time 2 times; Extracting solution directly adopts macroporous resin to carry out adsorbing separation and gets extract Radix Notoginseng total arasaponins fine powder after concentrating;

(3) by above-mentioned weight ratio, Radix Adenophorae (Radix Glehniae), Fructus Crataegi, Radix Salviae Miltiorrhizae are extracted through conventional water extraction process, process the extract fine powder, mix, stir, process Chinese medicine granules, capsule, tablet with above-mentioned (1), (2) two kinds of extract fine powders.